Wikileaks announced its intentions on Saturday, saying the organisation also planned to field a candidate to run against Prime Minister Julia Gillard in her seat of Lalor at the next election.
"We have discovered that it is possible for Julian Assange to run for the Australian Senate while detained. Julian has decided to run," the Wikileaks website tweeted.
Assange is being detained in England facing possible extradition to Sweden, where police want to question him over allegations that he sexually assaulted two women in 2010.